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- 鞚挫垬頇� 甑愳垬, "雮滌箻靹� 歆堩櫂鞐� ‘彀�靹鸽寑 頇橃瀽毵烄钉順� 鞎诫�检爠雼�鞁滌姢韰� 頂岆灚韽�’ 鞝侅毄 旮半寑"
- 甑�鞝滌爛氇� 頃欖垹歆� 銆孞ournal of Controlled Release銆� 瓴岇灛

鈻� 鞕检�诫秬韯� 鞚挫垬頇� 霃欔淡雽� 甑愳垬, Arai Yoshie 氚曥偓, 鞚挫劆欷� 氚曥偓瓿检爼靸�

霃欔淡雽赌顷欔祼(齑濎灔 鞙れ灛鞗�)電� 鞚橃儩氇呹车頃� 欷勱赴靹疙彫瓿淀暀 鞐瓣惮鞁れ潣 鞚挫垬頇� 甑愳垬 鞐瓣惮韺�(鞝�1鞝�鞛� 鞚挫劆欷� 氚曥偓瓿检爼靸�, 甑愳嫚鞝�鞛� 鞚挫垬頇� 甑愳垬, Arai Yoshie 氚曥偓)鞚� 頇橃瀽 毵烄钉順� 欷戧皠鞐届�勱赴靹疙彫 靹疙彫毵夑臣 韲错枆靹� 鞐瓣敞臁办�� 響滌爜頇� 韼╉儉鞚措摐毳� 鞚挫毄頃� 韲错枆靹� 瓿�甏�鞝堨椉 旃橂�岇毄 響滌爜頇� 鞎诫�检爠雼�鞁滌姢韰滌潉 臧滊皽頄堧嫟瓿� 氚濏様雼�.

順勳灛 韲错枆靹� 瓿�甏�鞝堨椉 旃橂�岆姅 靻岇椉歆勴喌鞝�, 鞀ろ厡搿滌澊霌� 欤检偓, 頌堨晫耄�搿犾偘 欤检偓鞝� 霌膘潣 鞎诫�检殧氩曥澊雮� 鞕戈臣鞝� 靾橃垹鞐� 欤茧�� 鞚橃〈頃橁碃 鞛堨溂雮�, 鞎诫�检潣 雮�鞚� 響滌爜 鞝勲嫭 須�鞙�, 氅挫棴 氚橃潙, 臧愳椉 鞙勴棙 霌膘潣 攵�鞛戩毄瓿� 頃滉硠毳� 臧�歆�瓿� 鞛堧嫟. 鞐瓣惮韺�鞚� 鞚措煬頃� 頃滉硠毳� 攴闺车頃橁赴 鞙勴暣 頇橃瀽鞚� 鞙犽弰毵岆姤欷勱赴靹疙彫(Induced Pluripotent Stem Cells, iPSCs)毳� 頇滌毄頃� 欷戧皠鞐届�勱赴靹疙彫(Mesenchymal Stem Cells, MSCs)毳� 鞝滌“頃橁碃, 頃措嫻 靹疙彫毵夓潉 鞚挫毄頃� 頇橃瀽 毵烄钉順� 鞎诫�� 鞝勲嫭觳措ゼ 臧滊皽頄堧嫟.

鞙犽弰毵岆姤欷勱赴靹疙彫鞐愳劀 鞏浑姅 欷戧皠鞐届�勱赴靹疙彫毵夓潃 頇橃瀽 氤胳澑鞚� 靹疙彫毳� 旮半皹鞙茧�� 頃橁赴 霑岆�胳棎 氅挫棴鞗愳劚鞚� 雮�瓿� 靸濎泊鞝來暕靹膘澊 霙办柎雮� 攵�鞛戩毄鞚� 斓滌唽頇旐暊 靾� 鞛堧嫟. 霕愴暅, 鞐瓣惮韺�鞚� 韲错枆靹� 瓿�甏�鞝堨椉 靻愳儊 鞐瓣敞鞐愲�� 瓴绊暕頃橂姅 響滌爜頇� 韼╉儉鞚措摐毳� 鞝勲嫭觳� 響滊┐鞐� 霃勳瀰頄堨溂氅�, 氤戨硛 攵�鞙勳棎 旃橂�岇牅毳� 韸轨澊鞝侅溂搿� 響滌爜頇旐暣 鞝勲嫭頃橂┐靹� 旃橂�� 須�電レ潉 攴闺寑頇旐暊 靾� 鞛堧弰搿� 靹り硠頄堧嫟.

鞐瓣惮 瓴瓣臣, 臁办�� 響滌爜頇� 鞎诫�检爠雼� 鞁滌姢韰滌潃 靻愳儊霅� 鞐瓣敞臁办�侅棎 韸轨澊鞝侅溂搿� 響滌爜頇旊悩氅�, 旮办〈 鞎诫�� 旃橂�岆炒雼� 鞗旊摫頌� 鞖办垬頃� 鞐瓣敞 鞛�靸� 氚� 頃�鞐� 須�瓿茧ゼ 鞛呾�濏晿鞓�雼�. 霕愴暅, 頇橃瀽 毵烄钉順� 靹疙彫毵夓潉 頇滌毄頃�鞙茧�滌崹 旮办〈 旃橂�岇牅鞚� 氍胳牅鞓�雿� 氅挫棴 瓯半秬 氚橃潙 鞐�鞁� 須�瓿检爜鞙茧�� 臧滌劆頃� 靾� 鞛堨潓鞚� 頇曥澑頄堧嫟.

鞚挫垬頇� 甑愳垬電� “鞚措矆 鞐瓣惮電� 旮办〈 旃橂�岇牅鞚� 頃滉硠毳� 霙办柎雱橃柎, 韸轨爼 臁办�侅棎 韸轨澊鞝侅溂搿� 鞎诫�检潉 鞝勲嫭頃� 靾� 鞛堧姅 彀�靹鸽寑 鞎诫�检爠雼�鞁滌姢韰� 頂岆灚韽� 臧滊皽鞚� 欷戩殧頃� 於滊皽鞝�”鞚措澕氅�, “頄ロ泟 韲错枆靹� 瓿�甏�鞝堨椉 旃橂�岆繍毵� 鞎勲媹霛� 雽�雼れ垬鞚� 雮滌箻靹� 歆堩櫂鞚� 響滌爜頇旐暣 旃橂�岉晿電� 鞁滌姢韰滌溂搿� 頇曤寑 鞝侅毄霅� 瓴冹溂搿� 旮半寑頃滊嫟”霛缄碃 旮半寑臧愳潉 氚濏様雼�.

頃措嫻 鞐瓣惮電� 頃滉淡鞐瓣惮鞛�雼� 欷戧铂鞐瓣惮歆�鞗愳偓鞐�, 彀届潣霃勳爠鞐瓣惮旮半皹歆�鞗愳偓鞐�, 頃挫櫢鞖办垬瓿柬暀鞛愳湢旃橃偓鞐�, 旮�搿滊矊旮办磮鞐瓣惮鞁れ��鞗愳偓鞐�, 頃滉淡靷办梾旮办垹歆勴潵鞗� 氚旍澊鞓る�旊敂旎� 旮�搿滊矊 鞚胳灛鞏戩劚靷�鞐呾潉 韱淀暣 靾橅枆霅橃棃鞙茧┌, 鞐瓣惮靹标臣電� <Curcumin-PLGA NPs coated with targeting biomimetic personalized stem cell membranes for osteoarthritis therapy>霛茧姅 鞝滊�╈溂搿� 鞎诫�检爠雼� 攵勳暭鞚� 靹戈硠鞝� 甓岇渼歆�鞚� SCI旮� 甑�鞝滍暀靾犾�� Journal of Controlled Release 381C, 2025, 113625 (IF=10.5, JCR 霝�韨� 靸侅渼 3.2%)鞐� 瓴岇灛霅橃棃雼�.